Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.
Identifieur interne : 000806 ( 2020/Analysis ); précédent : 000805; suivant : 000807Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.
Auteurs : Barry Rockx [Pays-Bas] ; Thijs Kuiken [Pays-Bas] ; Sander Herfst [Pays-Bas] ; Theo Bestebroer [Pays-Bas] ; Mart M. Lamers [Pays-Bas] ; Bas B. Oude Munnink [Pays-Bas] ; Dennis De Meulder [Pays-Bas] ; Geert Van Amerongen [Pays-Bas] ; Judith Van Den Brand [Pays-Bas] ; Nisreen M A. Okba [Pays-Bas] ; Debby Schipper [Pays-Bas] ; Peter Van Run [Pays-Bas] ; Lonneke Leijten [Pays-Bas] ; Reina Sikkema [Pays-Bas] ; Ernst Verschoor [Pays-Bas] ; Babs Verstrepen [Pays-Bas] ; Willy Bogers [Pays-Bas] ; Jan Langermans [Pays-Bas] ; Christian Drosten [Allemagne] ; Martje Fentener Van Vlissingen [Pays-Bas] ; Ron Fouchier [Pays-Bas] ; Rik De Swart [Pays-Bas] ; Marion Koopmans [Pays-Bas] ; Bart L. Haagmans [Pays-Bas]Source :
- Science (New York, N.Y.) [ 1095-9203 ] ; 2020.
Abstract
The current pandemic coronavirus, SARS-CoV-2, was recently identified in patients with an acute respiratory syndrome, COVID-19. To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or MERS-CoV and compared the pathology and virology with historical reports of SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs, and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. In SARS-CoV-infection, lung lesions were typically more severe, while they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 causes COVID-19-like disease in macaques, and provides a new model to test preventive and therapeutic strategies.
DOI: 10.1126/science.abb7314
PubMed: 32303590
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000045
- to stream PubMed, to step Curation: 000045
- to stream PubMed, to step Checkpoint: 000635
- to stream Ncbi, to step Merge: 003B55
- to stream Ncbi, to step Curation: 003B55
- to stream Ncbi, to step Checkpoint: 003B55
- to stream Main, to step Merge: 000806
- to stream Main, to step Curation: 000806
- to stream Main, to step Exploration: 000806
- to stream 2020, to step Extraction: 000806
Links to Exploration step
pubmed:32303590Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.</title><author><name sortKey="Rockx, Barry" sort="Rockx, Barry" uniqKey="Rockx B" first="Barry" last="Rockx">Barry Rockx</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands. b.rockx@erasmusmc.nl b.haagmans@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Herfst, Sander" sort="Herfst, Sander" uniqKey="Herfst S" first="Sander" last="Herfst">Sander Herfst</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Bestebroer, Theo" sort="Bestebroer, Theo" uniqKey="Bestebroer T" first="Theo" last="Bestebroer">Theo Bestebroer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Lamers, Mart M" sort="Lamers, Mart M" uniqKey="Lamers M" first="Mart M" last="Lamers">Mart M. Lamers</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Oude Munnink, Bas B" sort="Oude Munnink, Bas B" uniqKey="Oude Munnink B" first="Bas B" last="Oude Munnink">Bas B. Oude Munnink</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Meulder, Dennis" sort="De Meulder, Dennis" uniqKey="De Meulder D" first="Dennis" last="De Meulder">Dennis De Meulder</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name><affiliation wicri:level="1"><nlm:affiliation>Viroclinics Xplore, Schaijk, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Viroclinics Xplore, Schaijk</wicri:regionArea><wicri:noRegion>Schaijk</wicri:noRegion></affiliation></author><author><name sortKey="Van Den Brand, Judith" sort="Van Den Brand, Judith" uniqKey="Van Den Brand J" first="Judith" last="Van Den Brand">Judith Van Den Brand</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Okba, Nisreen M A" sort="Okba, Nisreen M A" uniqKey="Okba N" first="Nisreen M A" last="Okba">Nisreen M A. Okba</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Schipper, Debby" sort="Schipper, Debby" uniqKey="Schipper D" first="Debby" last="Schipper">Debby Schipper</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Run, Peter" sort="Van Run, Peter" uniqKey="Van Run P" first="Peter" last="Van Run">Peter Van Run</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Leijten, Lonneke" sort="Leijten, Lonneke" uniqKey="Leijten L" first="Lonneke" last="Leijten">Lonneke Leijten</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Sikkema, Reina" sort="Sikkema, Reina" uniqKey="Sikkema R" first="Reina" last="Sikkema">Reina Sikkema</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Verschoor, Ernst" sort="Verschoor, Ernst" uniqKey="Verschoor E" first="Ernst" last="Verschoor">Ernst Verschoor</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Biomedical Primate Research Centre, Rijswijk</wicri:regionArea><wicri:noRegion>Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="Verstrepen, Babs" sort="Verstrepen, Babs" uniqKey="Verstrepen B" first="Babs" last="Verstrepen">Babs Verstrepen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Biomedical Primate Research Centre, Rijswijk</wicri:regionArea><wicri:noRegion>Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="Bogers, Willy" sort="Bogers, Willy" uniqKey="Bogers W" first="Willy" last="Bogers">Willy Bogers</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Biomedical Primate Research Centre, Rijswijk</wicri:regionArea><wicri:noRegion>Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="Langermans, Jan" sort="Langermans, Jan" uniqKey="Langermans J" first="Jan" last="Langermans">Jan Langermans</name><affiliation wicri:level="1"><nlm:affiliation>Animal Science Department, Biomedical Primate Research Centre, Rijswijk, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Animal Science Department, Biomedical Primate Research Centre, Rijswijk</wicri:regionArea><wicri:noRegion>Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, Charité-Universitätsmedizin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Charité-Universitätsmedizin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Fentener Van Vlissingen, Martje" sort="Fentener Van Vlissingen, Martje" uniqKey="Fentener Van Vlissingen M" first="Martje" last="Fentener Van Vlissingen">Martje Fentener Van Vlissingen</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus Laboratory Animal Science Center, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Erasmus Laboratory Animal Science Center, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Fouchier, Ron" sort="Fouchier, Ron" uniqKey="Fouchier R" first="Ron" last="Fouchier">Ron Fouchier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Swart, Rik" sort="De Swart, Rik" uniqKey="De Swart R" first="Rik" last="De Swart">Rik De Swart</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Koopmans, Marion" sort="Koopmans, Marion" uniqKey="Koopmans M" first="Marion" last="Koopmans">Marion Koopmans</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands. b.rockx@erasmusmc.nl b.haagmans@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32303590</idno><idno type="pmid">32303590</idno><idno type="doi">10.1126/science.abb7314</idno><idno type="wicri:Area/PubMed/Corpus">000045</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000045</idno><idno type="wicri:Area/PubMed/Curation">000045</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000045</idno><idno type="wicri:Area/PubMed/Checkpoint">000635</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000635</idno><idno type="wicri:Area/Ncbi/Merge">003B55</idno><idno type="wicri:Area/Ncbi/Curation">003B55</idno><idno type="wicri:Area/Ncbi/Checkpoint">003B55</idno><idno type="wicri:Area/Main/Merge">000806</idno><idno type="wicri:Area/Main/Curation">000806</idno><idno type="wicri:Area/Main/Exploration">000806</idno><idno type="wicri:Area/2020/Extraction">000806</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.</title><author><name sortKey="Rockx, Barry" sort="Rockx, Barry" uniqKey="Rockx B" first="Barry" last="Rockx">Barry Rockx</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands. b.rockx@erasmusmc.nl b.haagmans@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Herfst, Sander" sort="Herfst, Sander" uniqKey="Herfst S" first="Sander" last="Herfst">Sander Herfst</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Bestebroer, Theo" sort="Bestebroer, Theo" uniqKey="Bestebroer T" first="Theo" last="Bestebroer">Theo Bestebroer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Lamers, Mart M" sort="Lamers, Mart M" uniqKey="Lamers M" first="Mart M" last="Lamers">Mart M. Lamers</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Oude Munnink, Bas B" sort="Oude Munnink, Bas B" uniqKey="Oude Munnink B" first="Bas B" last="Oude Munnink">Bas B. Oude Munnink</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Meulder, Dennis" sort="De Meulder, Dennis" uniqKey="De Meulder D" first="Dennis" last="De Meulder">Dennis De Meulder</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name><affiliation wicri:level="1"><nlm:affiliation>Viroclinics Xplore, Schaijk, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Viroclinics Xplore, Schaijk</wicri:regionArea><wicri:noRegion>Schaijk</wicri:noRegion></affiliation></author><author><name sortKey="Van Den Brand, Judith" sort="Van Den Brand, Judith" uniqKey="Van Den Brand J" first="Judith" last="Van Den Brand">Judith Van Den Brand</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Okba, Nisreen M A" sort="Okba, Nisreen M A" uniqKey="Okba N" first="Nisreen M A" last="Okba">Nisreen M A. Okba</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Schipper, Debby" sort="Schipper, Debby" uniqKey="Schipper D" first="Debby" last="Schipper">Debby Schipper</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Run, Peter" sort="Van Run, Peter" uniqKey="Van Run P" first="Peter" last="Van Run">Peter Van Run</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Leijten, Lonneke" sort="Leijten, Lonneke" uniqKey="Leijten L" first="Lonneke" last="Leijten">Lonneke Leijten</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Sikkema, Reina" sort="Sikkema, Reina" uniqKey="Sikkema R" first="Reina" last="Sikkema">Reina Sikkema</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Verschoor, Ernst" sort="Verschoor, Ernst" uniqKey="Verschoor E" first="Ernst" last="Verschoor">Ernst Verschoor</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Biomedical Primate Research Centre, Rijswijk</wicri:regionArea><wicri:noRegion>Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="Verstrepen, Babs" sort="Verstrepen, Babs" uniqKey="Verstrepen B" first="Babs" last="Verstrepen">Babs Verstrepen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Biomedical Primate Research Centre, Rijswijk</wicri:regionArea><wicri:noRegion>Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="Bogers, Willy" sort="Bogers, Willy" uniqKey="Bogers W" first="Willy" last="Bogers">Willy Bogers</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Biomedical Primate Research Centre, Rijswijk</wicri:regionArea><wicri:noRegion>Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="Langermans, Jan" sort="Langermans, Jan" uniqKey="Langermans J" first="Jan" last="Langermans">Jan Langermans</name><affiliation wicri:level="1"><nlm:affiliation>Animal Science Department, Biomedical Primate Research Centre, Rijswijk, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Animal Science Department, Biomedical Primate Research Centre, Rijswijk</wicri:regionArea><wicri:noRegion>Rijswijk</wicri:noRegion></affiliation></author><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Virology, Charité-Universitätsmedizin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Virology, Charité-Universitätsmedizin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Fentener Van Vlissingen, Martje" sort="Fentener Van Vlissingen, Martje" uniqKey="Fentener Van Vlissingen M" first="Martje" last="Fentener Van Vlissingen">Martje Fentener Van Vlissingen</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus Laboratory Animal Science Center, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Erasmus Laboratory Animal Science Center, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Fouchier, Ron" sort="Fouchier, Ron" uniqKey="Fouchier R" first="Ron" last="Fouchier">Ron Fouchier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Swart, Rik" sort="De Swart, Rik" uniqKey="De Swart R" first="Rik" last="De Swart">Rik De Swart</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Koopmans, Marion" sort="Koopmans, Marion" uniqKey="Koopmans M" first="Marion" last="Koopmans">Marion Koopmans</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name><affiliation wicri:level="3"><nlm:affiliation>Department of Viroscience, Erasmus University Medical Center, Rotterdam, Netherlands. b.rockx@erasmusmc.nl b.haagmans@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j">Science (New York, N.Y.)</title><idno type="eISSN">1095-9203</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The current pandemic coronavirus, SARS-CoV-2, was recently identified in patients with an acute respiratory syndrome, COVID-19. To compare its pathogenesis with that of previously emerging coronaviruses, we inoculated cynomolgus macaques with SARS-CoV-2 or MERS-CoV and compared the pathology and virology with historical reports of SARS-CoV infections. In SARS-CoV-2-infected macaques, virus was excreted from nose and throat in the absence of clinical signs, and detected in type I and II pneumocytes in foci of diffuse alveolar damage and in ciliated epithelial cells of nasal, bronchial, and bronchiolar mucosae. In SARS-CoV-infection, lung lesions were typically more severe, while they were milder in MERS-CoV infection, where virus was detected mainly in type II pneumocytes. These data show that SARS-CoV-2 causes COVID-19-like disease in macaques, and provides a new model to test preventive and therapeutic strategies.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Pays-Bas</li></country><region><li>Berlin</li><li>Hollande-Méridionale</li></region><settlement><li>Berlin</li><li>Rotterdam</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Rockx, Barry" sort="Rockx, Barry" uniqKey="Rockx B" first="Barry" last="Rockx">Barry Rockx</name></region><name sortKey="Bestebroer, Theo" sort="Bestebroer, Theo" uniqKey="Bestebroer T" first="Theo" last="Bestebroer">Theo Bestebroer</name><name sortKey="Bogers, Willy" sort="Bogers, Willy" uniqKey="Bogers W" first="Willy" last="Bogers">Willy Bogers</name><name sortKey="De Meulder, Dennis" sort="De Meulder, Dennis" uniqKey="De Meulder D" first="Dennis" last="De Meulder">Dennis De Meulder</name><name sortKey="De Swart, Rik" sort="De Swart, Rik" uniqKey="De Swart R" first="Rik" last="De Swart">Rik De Swart</name><name sortKey="Fentener Van Vlissingen, Martje" sort="Fentener Van Vlissingen, Martje" uniqKey="Fentener Van Vlissingen M" first="Martje" last="Fentener Van Vlissingen">Martje Fentener Van Vlissingen</name><name sortKey="Fouchier, Ron" sort="Fouchier, Ron" uniqKey="Fouchier R" first="Ron" last="Fouchier">Ron Fouchier</name><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L" last="Haagmans">Bart L. Haagmans</name><name sortKey="Herfst, Sander" sort="Herfst, Sander" uniqKey="Herfst S" first="Sander" last="Herfst">Sander Herfst</name><name sortKey="Koopmans, Marion" sort="Koopmans, Marion" uniqKey="Koopmans M" first="Marion" last="Koopmans">Marion Koopmans</name><name sortKey="Kuiken, Thijs" sort="Kuiken, Thijs" uniqKey="Kuiken T" first="Thijs" last="Kuiken">Thijs Kuiken</name><name sortKey="Lamers, Mart M" sort="Lamers, Mart M" uniqKey="Lamers M" first="Mart M" last="Lamers">Mart M. Lamers</name><name sortKey="Langermans, Jan" sort="Langermans, Jan" uniqKey="Langermans J" first="Jan" last="Langermans">Jan Langermans</name><name sortKey="Leijten, Lonneke" sort="Leijten, Lonneke" uniqKey="Leijten L" first="Lonneke" last="Leijten">Lonneke Leijten</name><name sortKey="Okba, Nisreen M A" sort="Okba, Nisreen M A" uniqKey="Okba N" first="Nisreen M A" last="Okba">Nisreen M A. Okba</name><name sortKey="Oude Munnink, Bas B" sort="Oude Munnink, Bas B" uniqKey="Oude Munnink B" first="Bas B" last="Oude Munnink">Bas B. Oude Munnink</name><name sortKey="Schipper, Debby" sort="Schipper, Debby" uniqKey="Schipper D" first="Debby" last="Schipper">Debby Schipper</name><name sortKey="Sikkema, Reina" sort="Sikkema, Reina" uniqKey="Sikkema R" first="Reina" last="Sikkema">Reina Sikkema</name><name sortKey="Van Amerongen, Geert" sort="Van Amerongen, Geert" uniqKey="Van Amerongen G" first="Geert" last="Van Amerongen">Geert Van Amerongen</name><name sortKey="Van Den Brand, Judith" sort="Van Den Brand, Judith" uniqKey="Van Den Brand J" first="Judith" last="Van Den Brand">Judith Van Den Brand</name><name sortKey="Van Run, Peter" sort="Van Run, Peter" uniqKey="Van Run P" first="Peter" last="Van Run">Peter Van Run</name><name sortKey="Verschoor, Ernst" sort="Verschoor, Ernst" uniqKey="Verschoor E" first="Ernst" last="Verschoor">Ernst Verschoor</name><name sortKey="Verstrepen, Babs" sort="Verstrepen, Babs" uniqKey="Verstrepen B" first="Babs" last="Verstrepen">Babs Verstrepen</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/2020/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000806 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/2020/Analysis/biblio.hfd -nk 000806 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= 2020
|étape= Analysis
|type= RBID
|clé= pubmed:32303590
|texte= Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/2020/Analysis/RBID.i -Sk "pubmed:32303590" \
| HfdSelect -Kh $EXPLOR_AREA/Data/2020/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |